Description
Mechanism of Action:
This class of drugs is a fast-acting bacterial inhibitor. After entering the bacterium, it reversibly binds to the receptor on the 30S subunit of the bacterial ribosome, interferes with the binding of tRNA to the receptor on the mRNA-ribosome complex, prevents the extension of peptide chain and inhibits protein synthesis, so that the growth and reproduction of bacteria are rapidly inhibited. There are two main ways for tunicamycin to enter the cell: one is passive diffusion through the hydrophilic group of the outer cell membrane; the other is active transport by the inner cell.
Efficacy:
1.Dysentery caused by E. coli or Salmonella, such as yellow and white dysentery in piglets, white dysentery in chicks, etc.
2.Swine pneumonia and avian cholera caused by Pasteurella multocida.
3.Control of swine proliferative enteritis (ileitis) caused by Lawsonia intracellulare.
4.Control leptospirosis caused by Leptospira Pomona (reduce the incidence of abortion and leptospirosis shedding).
5.Reduce the incidence of cervical lymphadenitis (jaw abscess) caused by group E streptococci.
6.Mycoplasma-induced asthma in pigs, chronic respiratory diseases in chickens, etc.
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Notes:
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